Ore no Imouto ga Konnani Kawaii Wake ga Nai.
Anime ini bercerita tentang kehidupan Kousaka Kyousuke yang sudah bertahun-tahun tidak akur dengan adik perempuannya sendiri, yaitu Kousaka Kirino. Suatu hari, Kyousuke menemukan DVD dan ternyata, di dalamnya terdapat game eroge dengan judul Love with Imouto (Bercinta dengan adik perempuan). Tentu hal ini sangat mengejutkan Kyousuke. Karena penasaran, dia pun memutuskan untuk mencari tau siapa pemilik game eroge tersebut.
Hingga pada akhirnya, dia menemukan kalau pemiliknya tak lain adalah adiknya sendiri. Lucunya, insiden itu justru membuat hubungan mereka lambat laun makin membaik. Dengan dalih ‘bimbingan konseling’, Kirino pun memaksa Kyosuke untuk ikut terjun ke dalam hobi laknatnya tersebut.
Lagu Pembuka
1: "reunion" by ClariS (eps 2-8, 11-13)
2: "Hoshikuzu Cosplay☆Witch! Desu! Omega! (星くずこすぷれ☆うぃっち！です！)" by Bridget Evans (CV: Misaki Kuno) (eps 10)
2: "Hoshikuzu Cosplay☆Witch! Desu! Omega! (星くずこすぷれ☆うぃっち！です！)" by Bridget Evans (CV: Misaki Kuno) (eps 10)
Lagu Penutup
1: "Kanjou-sen loop (感情線loop)" by Kirino Kousaka (CV: Ayana Taketatsu) (eps 1)
2: "Filter (フィルター)" by Ayase Aragaki (CV: Saori Hayami) (eps 2)
3: "Zutto... (ずっと...)" by Kirino Kousaka, Kuroneko, and Saori Bajeena (CV: Ayana Taketatsu, Kana Hanazawa, and Hitomi Nabatame) (eps 3)
4: "Honest☆Rhapsody (ほねすと☆ラプソディー)" by Kirino Kousaka (CV: Ayana Taketatsu) (eps 4)
5: "Keep" by Kirino Kousaka (CV: Ayana Taketatsu) (eps 5)
6: "Monochrome☆HAPPY DAY (モノクロ☆HAPPY DAY)" by Kuroneko (CV: Kana Hanazawa) (eps 6)
7: "Kyou mo Shiawase (きょうもしあわせ)" by Tamaki Gokou (CV: Yui Ogura) (eps 7)
8: "Setsuna no Destiny (刹那のDestiny)" by Kuroneko (CV: Kana Hanazawa) (eps 8)
9: "answer" by Kirino Kousaka (CV: Ayana Taketatsu) (eps 9)
10: "reunion" by ClariS (eps 10)
11: "Arifureta Mirai he (ありふれた未来へ)" by Manami Tamura (CV: Satomi Satou) (eps 11)
12: "Omou Koto (想うコト) (Things that i think)" by Ayase Aragaki (CV: Saori Hayami) (eps 12)
13: "Honto no Kimochi (ホントの気持ち)" by Kirino Kousaka and Manami Tamura (CV: Ayana Taketatsu and Satomi Satou) (eps 13)
2: "Filter (フィルター)" by Ayase Aragaki (CV: Saori Hayami) (eps 2)
3: "Zutto... (ずっと...)" by Kirino Kousaka, Kuroneko, and Saori Bajeena (CV: Ayana Taketatsu, Kana Hanazawa, and Hitomi Nabatame) (eps 3)
4: "Honest☆Rhapsody (ほねすと☆ラプソディー)" by Kirino Kousaka (CV: Ayana Taketatsu) (eps 4)
5: "Keep" by Kirino Kousaka (CV: Ayana Taketatsu) (eps 5)
6: "Monochrome☆HAPPY DAY (モノクロ☆HAPPY DAY)" by Kuroneko (CV: Kana Hanazawa) (eps 6)
7: "Kyou mo Shiawase (きょうもしあわせ)" by Tamaki Gokou (CV: Yui Ogura) (eps 7)
8: "Setsuna no Destiny (刹那のDestiny)" by Kuroneko (CV: Kana Hanazawa) (eps 8)
9: "answer" by Kirino Kousaka (CV: Ayana Taketatsu) (eps 9)
10: "reunion" by ClariS (eps 10)
11: "Arifureta Mirai he (ありふれた未来へ)" by Manami Tamura (CV: Satomi Satou) (eps 11)
12: "Omou Koto (想うコト) (Things that i think)" by Ayase Aragaki (CV: Saori Hayami) (eps 12)
13: "Honto no Kimochi (ホントの気持ち)" by Kirino Kousaka and Manami Tamura (CV: Ayana Taketatsu and Satomi Satou) (eps 13)